Association of dietary macronutrients with MRI-detected vascular brain injury and cognition in 9886 middle-aged participants from four countries: for the Canadian Alliance of Healthy Hearts and Minds (CAHHM) and the Prospective Urban Rural Epidemiolog<b>ical</b> (PURE) Study Investigators.

ABSTRACT:

Background

Epidemiologic evidence relating macronutrient intake and changes in the brain and cognition are limited. We assessed the associations of macronutrient consumption, including carbohydrate, protein, total fat, saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids, with vascular brain injury and cognitive scores.

Methods

We analyzed cross-sectional data from 9886 middle-aged adults in four countries free of clinically apparent cardiovascular disease from the Canadian Alliance for Healthy Hearts and Minds (CAHHM) and the Prospective Urban Rural Epidemiological MIND (PURE-MIND) studies. Participants from CAHHM were recruited from January 1, 2014 to December 31, 2018, and PURE-MIND participants were recruited from January 1, 2010 to Decembe

SUBMITTER: Miller V 

PROVIDER: S-EPMC12284712 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature