Ultra-low dose superparamagnetic iron oxide nanoparticle injection for sentinel lymph node detection in breast cancer: prospective cohort study.

ABSTRACT:

Background

Sentinel lymph node (SLN) staging is essential in breast cancer. Superparamagnetic iron oxide nanoparticles (SPIO) is a tracer where the optimal injection technique is yet not defined. The aim was to evaluate SLN detection using 0.1 ml SPIO intradermally compared to technetium-99 m (Tc99) ± blue dye.

Method

Patients planned for breast surgery and SLN biopsy received 0.1 ml SPIO intradermally at the areolar border or over the tumour. Tc99 ± blue dye was administered per clinical routine. Magnetic, radioactive, or blue nodes were removed and analysed separately. SLN detection and numbers, concordance, and skin discoloration were analysed.

Results

A total of 216 patients were included at five hospitals. Median age was 63 years, tumour size 15.9 mm, and 91.7% u

SUBMITTER: Sundh L 

PROVIDER: S-EPMC12284759 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature