Successful Management of Neonatal and Infantile Kaposiform Hemangioendothelioma with Low-Dose Sirolimus Therapy.

ABSTRACT: Sirolimus is reportedly effective for kaposiform hemangioendothelioma. However, data on the efficacy of low-dose sirolimus therapy remain limited. This report presents two cases of neonatal and infantile kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon successfully treated with low-dose sirolimus (serum level: 2-6 ng/mL) without any adverse events.

SUBMITTER: Uematsu Y 

PROVIDER: S-EPMC12284785 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature