Invasive vs Conservative Management of Patients With Chronic Total Occlusion: Results From the ISCHEMIA Trial.

ABSTRACT:

Background

Randomized trials of chronic total occlusion (CTO) revascularization vs medical therapy have yielded inconsistent results.

Objectives

The aim of this study was to evaluate outcomes with an initial invasive strategy (INV) vs an initial conservative strategy (CON) in patients with coronary computed tomographic angiography (CCTA)-determined CTO in the ISCHEMIA (International Study of Comparative Health Effectiveness With Medical and Invasive Approaches) trial.

Methods

Participants in ISCHEMIA who underwent CCTA evaluated for CTO by the core laboratory (3,113 of 5,179 randomized patients [60%]) were categorized into subgroups with (100% stenosis) and without (<100% stenosis) CTO. Primary analysis compared outcomes in those randomized to INV vs CON using an inte

SUBMITTER: Bangalore S 

PROVIDER: S-EPMC12284807 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature