Tautomer aspects in the excited-state dynamics in 2-thiocytosine: intersystem crossing in the absence of the thiocarbonyl group.

ABSTRACT: Molecular tautomerism is ubiquitous in nature and plays a crucial role in regulating biological function. In nucleobases, for example, structural tautomerism not only influences base pairing and genetic coding in DNA but also modulates the molecular response to UV irradiation. The photostability of the nucleobases depends on efficient internal conversion and is highly sensitive to structural variations and micro-environmental effects. Among the pyrimidine bases, cytosine exhibits the greatest number of tautomeric forms, offering a rich landscape to explore diverse structural scenarios, while simultaneously posing significant experimental challenges. This study builds on that context by unveiling the gas-phase photophysics of 2-thiocytosine (2TC) from a unique tautomer perspective. Specific

SUBMITTER: Duwal B 

PROVIDER: S-EPMC12284813 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature