Silver Binding Dichotomy for 7-Deazaadenine/Thymine: Preference for Watson-Crick Pairing over Homobase Interactions in DNA.

ABSTRACT: DNA strands modified with 7-deazaadenine (X) and 7-deazaguanine (Y) have shown promise in forming silver-DNA assemblies while maintaining canonical Watson-Crick base pairing, highlighting the compatibility of silver binding with standard DNA structures. However, critical questions remain regarding the binding preferences of Ag^I ions to sequences containing 7-deazapurine bases, particularly the prevalence of silver-modified Watson-Crick base pairs versus alternative homobase pair arrangements. To address this, we examined the binding of Ag^I to complementary X-T sequences, demonstrating a strong preference for canonical X-Ag^I-T pairing over homoleptic X-Ag^I-X or T-Ag^I-T pairs. Additionally, we report the discovery of a novel metallized D

SUBMITTER: Lopez-Chamorro C 

PROVIDER: S-EPMC12284849 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature