Long-Term Antibiofilm Efficacy of Slippery Covalently Attached Liquid-like Surfaces in Dynamic and Static Culture Conditions.

ABSTRACT: This study explores the antibiofilm potential of slippery covalently attached liquid-like surfaces, revealing their remarkable ability to inhibit biofilm formation over extended periods, regardless of their hydrophobic or hydrophilic nature. We engineered permanently bound liquid-like solid surfaces with exceptional slipperiness, defined by ultralow contact angle hysteresis, and assessed their effectiveness against two nosocomial pathogens, Pseudomonas aeruginosa (PAO1) and Staphylococcus epidermidis (FH8). These surfaces achieved a 3-5 order of magnitude reduction in biofilm formation compared to polydimethylsiloxane under both static and dynamic culture conditions over 14 days. Impressively, both the hydrophobic and hydrophilic slippery liquid-like solid surfaces significan

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12284853 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature