Uptake Mechanism of Riboflavin-Functionalized Superparamagnetic Iron Oxide Nanoparticles in Triple-Negative Breast Cancer Cells.

ABSTRACT: Superparamagnetic iron oxide nanoparticles (SPIONs), which are widely used as contrast agents in magnetic resonance imaging and as magnetic hyperthermia agents in cancer therapy, can be functionalized with biological molecules to enhance their specificity, stability, and cellular interaction. Riboflavin (Rf), a crucial biomolecule in cellular metabolism, is a potentially effective targeting moiety that can be selectively transported via riboflavin transporters (RFVTs), which are often overexpressed in cancer cells, including breast cancer cells. Here, we synthesize Rf-functionalized SPIONs (Rf-SPIONs) with high colloidal stability and stronger cellular interaction with breast cancer cells (MCF-7, and MDA-MB-231) than with normal breast cells (MCF-10A). Notably, the uptake is highest in tri

SUBMITTER: Nuchpun S 

PROVIDER: S-EPMC12284854 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature