Standardization of TSH and FT4 to gestational age in early pregnancy and associations with clinical outcomes.

ABSTRACT:

Background

To account for pregnancy-specific changes in thyroid physiology, international guidelines recommend the use of trimester-specific reference intervals. However, the pragmatic division in trimesters does not necessarily align with the changes in thyroid physiology. While the goal of treating gestational thyroid dysfunction is to prevent thyroid hormone-mediated adverse events, it remains unclear which method of standardizing to gestational age, if any, is most effective in identifying individuals at higher risk of adverse pregnancy events.

Methods

We included 5,675 women participating in a population-based prospective cohort with data on thyroid-stimulating hormone (TSH), free thyroxine (FT4) and thyroperoxidase antibodies (TPOAbs) during early pregnancy (median: 13

SUBMITTER: Osinga JAJ 

PROVIDER: S-EPMC12284872 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature