YAP as a therapeutic target in esophageal squamous cell carcinoma: insights and strategies.

ABSTRACT:

Background

Yes-associated protein (YAP) is a core component of the Hippo pathway, which functions as an oncogene in various cancers. However, emerging evidence has shown that YAP can also act as a tumor suppressor. Therefore, understanding the function and molecular mechanism of YAP is crucial for developing YAP-targeted drugs in tumors.

Methods

A comprehensive literature review was conducted. The review mainly includes the post-translational modification, the regulatory mechanisms and function of YAP in esophageal squamous cell carcinoma (ESCC).

Results

YAP undergoes various post-translational modifications (PTMs), including phosphorylation, ubiquitination, acetylation and others, which critically regulate its protein stability and transcriptional activity in multipl

SUBMITTER: Wang W 

PROVIDER: S-EPMC12284994 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature