Donor-derived microbial engraftment and gut microbiota shifts associated with weight loss following fecal microbiota transplantation.

ABSTRACT: Fecal microbiota transplantation (FMT) is a promising treatment for microbiota dysbiosis and may provide metabolic benefits for obesity. However, its mechanisms and variability in clinical outcomes remain poorly understood. This 12-week multicenter, single-arm study evaluated the efficacy of FMT for weight loss and explored the role of donor-derived microbial engraftment and functional shifts in mediating weight loss among overweight and obese individuals. Twenty-three participants (body mass index ≥24 kg/m²) without diabetes received three biweekly FMT sessions via a nasojejunal tube. Fecal samples from participants and donors were analyzed using metagenomic sequencing. By week 12, 52% of participants were classified as responders, achieving significant weight loss of ≥5% from baseline, w

SUBMITTER: Ruan Y 

PROVIDER: S-EPMC12285249 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature