Phenotypic analysis of various <i>Clostridioides difficile</i> ribotypes reveals consistency among core processes.

ABSTRACT: Clostridioides difficile infections (CDI) cause almost 300,000 hospitalizations per year, of which ~15%-30% are the result of recurring infections. The prevalence and persistence of CDI in hospital settings have resulted in an extensive collection of C. difficile clinical isolates and their classification, typically by ribotype. While much of the current literature focuses on one or two prominent epidemic ribotypes (e.g., RT027), recent years have seen several other ribotypes dominate the clinical landscape (e.g., RT106 and RT078). Some ribotypes are associated with severe disease and/or increased recurrence rates, but why certain ribotypes are more prominent or harmful than others remains unknown. Because C. difficile has a large, open pan-genome, this observed relati

SUBMITTER: Beebe MA 

PROVIDER: S-EPMC12285255 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature