Chronic hexavalent chromium exposure induces oxidative stress-mediated molecular cascades in Thymallus grubii gills: evidence from integrated transcriptomics and metabolomics.

ABSTRACT:

Introduction

Cr(VI) is a heavy metal contaminant, can diffuse to ecosystems and harm aquatic animals. Gills, as a vital organ in direct contact with the aquatic environment, have become a key target tissue for assessing the toxicological effects of heavy metal pollution of water bodies due to their sensitivity to heavy metal exposure. However, 3the effects of Cr(VI) on the gill tissues in fish have been less studied. In this study, we revealed the multiple effects of chromium toxicity by assessing the oxidative damage, transcriptomic and metabolomic changes of Cr(VI) on gill tissues of Thymallus grubii.

Methods

A total of 270 fishes were stratified into three experimental groups: control group, low-concentration exposure group (0.2 mg/L), and high-concentration exposu

SUBMITTER: Shang X 

PROVIDER: S-EPMC12285536 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature