Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial.

ABSTRACT:

Importance

Despite the widespread use of systemic antibiotics to prevent infections in surgically treated patients with fracture, high rates of surgical site infection persist.

Objective

To examine the effect of intrawound vancomycin powder in reducing deep surgical site infections.

Design, setting, and participants

This open-label randomized clinical trial enrolled adult patients with an operatively treated tibial plateau or pilon fracture who met the criteria for a high risk of infection from January 1, 2015, through June 30, 2017, with 12 months of follow-up (final follow-up assessments completed in April 2018) at 36 US trauma centers.

Interventions

A standard infection prevention protocol with (n = 481) or without (n = 499) 1000 mg of intrawound vancomycin

SUBMITTER: Major Extremity Trauma Research Consortium (METRC) 

PROVIDER: S-EPMC12285540 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature