Single Extracellular Vesicle Profiling to Define Brain Specific Traumatic Brain Injury Induced Neuro-Inflammation.

ABSTRACT: Traumatic Brain Injury (TBI) triggers secondary molecular processes that contribute to mortality and morbidity. Neuroinflammation is a key factor affecting patient outcomes both acutely and chronically. Traditional diagnostic tools, such as computed tomography imaging and the Glasgow Coma Scale, are limited in detecting molecular changes, particularly related to neuroinflammation. Small extracellular vesicles (sEVs) are cell-specific vesicles that enable cell-to-cell communication and are involved in TBI pathology. In this study, brain-specific sEVs are isolated by targeting brain-associated markers, sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2) and excitatory amino acid transporter 2 (EAAT2), and employed surface-enhanced Raman spectroscopy to profile inflammation-associate

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12285632 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature