A General Approach to Predict and Tailor the Nanoscale Permeability of Comb-Shaped Polymer Coatings.

ABSTRACT: Comb-shaped polymers such as poly(oligoethylene glycol monomethyl ether) methacrylate) (pOEGMA) are used to produce molecular sieving coatings on proteins. The mechanisms and phenomena implicated in the experimentally observed sieving properties have been recently characterized by simulation. These result from an interplay between steric hindrance, microenvironmental effects, and modified protein dynamics. Steric hindrance, in particular, is expected to vary considerably as a function of the geometric parameters of the system (protein size, polymer size, grafting density, etc.). In this work, the steric and size-selective permeability characteristics of comb-polymer coatings are systematically explored across a very broad parameter space to gain a universal and predictive view of molecular

SUBMITTER: Drossis N 

PROVIDER: S-EPMC12285633 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature