Traditional herbal medicine for the prevention of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis with association rule analysis.

ABSTRACT:

Introduction

This systematic review and meta-analysis evaluated the preventive efficacy and safety of orally-administered traditional herbal medicine (THM) for the management of chemotherapy-induced peripheral neuropathy (CIPN) in patients with cancer.

Methods

Randomized controlled trials (RCTs) evaluating the efficacy of orally-administered THM in the prevention of CIPN published up to 30 April 2024 were retrieved from nine databases. The primary outcome was the incidence of CIPN, and the secondary outcomes included changes in neuropathic pain intensity, nerve conduction study parameters, Karnofsky Performance Scale (KPS) scores, and the incidence of adverse events. The quality of the studies and the strength of the evidence were evaluated using the Cochrane Risk of Bias As

SUBMITTER: Kim EH 

PROVIDER: S-EPMC12285655 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature