Prevalence of at-risk MASH, MetALD and alcohol-associated steatotic liver disease in the general population.

ABSTRACT:

Background

The prevalence of at-risk metabolic dysfunction-associated steatohepatitis (at-risk MASH) has not been systematically assessed.

Aim

To delineate the prevalence of at-risk MASH in a large population-based cohort.

Methods

We conducted a cross-sectional analysis of 40,189 patients in the UK Biobank who underwent liver MRI. Hepatic steatosis was determined by proton density fat fraction (PDFF) ≥5%. Based on AASLD criteria, participants were classified as alcohol-associated steatotic liver disease (ALD), metabolic dysfunction-associated steatotic liver disease (MASLD), combined metabolic alcoholic liver disease (MetALD) and at-risk MASH.

Results

Among 40,189 patients, 10,886 (27.0%) had a PDFF ≥5%, indicating SLD. Among patients with SLD, 1% had ALD, 89.0

SUBMITTER: Schneider CV 

PROVIDER: S-EPMC12285740 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature