Increased alcohol-biased choice behavior in mouse models of high alcohol drinking.

ABSTRACT:

Background

Rodent models have explored the transition from controlled goal-directed consumption to habitual/compulsive intake using different procedures. This study evaluates the effect of concurrent presentation of sucrose on alcohol intake using two models that induce high levels of alcohol intake in mice that experienced chronic intermittent ethanol (CIE) exposure and/or stress.

Methods

In Experiment 1, male mice were exposed to four cycles of CIE or control (air) exposure, and once an increase in voluntary alcohol was observed in CIE mice, mice were offered a choice between alcohol or increasing concentrations of sucrose (from 0.75% to 12%; w/v). In Experiment 2, male mice experienced three cycles of CIE exposure, CIE and forced swim stress, control (air) exposure, or fo

SUBMITTER: Lopez MF 

PROVIDER: S-EPMC12285916 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature