Distinct populations suppress or escalate intake of cocaine paired with aversive quinine.

ABSTRACT:

Background

Only a subset of individuals who encounter illicit drugs become persons with a substance use disorder. Individual differences in aversive reactions to drug-associated phenomena like smoke inhalation and unpleasant taste are predictors for continued use. While several preclinical studies have explored self-administration involving aversive cues, none have simultaneously introduced aversion with the initial drug self-administration. We aimed to develop such a model by pairing intravenous cocaine with intraoral quinine self-administration from the outset and investigate whether repeated exposure to an aversive stimulus would alter its hedonic value under laboratory conditions.

Methods

Twenty-seven male and female Sprague Dawley rats self-administered intravenous/intr

SUBMITTER: Powers RE 

PROVIDER: S-EPMC12286316 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature