A role for Myo-II zipper and spaghetti squash in Gliotactin-dependent Drosophila melanogaster wing hair planar cell polarity.

ABSTRACT: Planar cell polarity, polarization in the plane of an epithelium, is critical for tissue development. The Drosophila melanogaster wing epithelium is an important model system for planar cell polarity establishment and has greatly informed studies in vertebrates. The well-studied Frizzled-dependent and Fat - Dachsous - Four-jointed pathways establish proximal-to-distal polarity of wing hairs, while a Frizzled-independent mechanism mediated by septate junction proteins Gliotactin, Coracle, and Varicose is required for parallel alignment of neighboring hairs. In this study, we explore a requirement for the non-muscle myosin II proteins Spaghetti Squash and Zipper in wing hair planar cell polarity. We confirm a previously recognized role in hair initiation and demonstrate a second, novel Gliot

SUBMITTER: Holland C 

PROVIDER: S-EPMC12286378 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature