Pre-conditioning with PQQ during pregnancy alleviates LPS-induced placental damage and improves the fetal survival and growth in mice.

ABSTRACT:

Background

Intrauterine infection is a major cause of preterm birth, fetal demise, and growth restriction. Placental damage resulting from such infections plays a central role in mediating these adverse outcomes. Pyrroloquinoline quinone (PQQ) is a naturally occurring nutrient known for its antioxidant, anti-inflammatory, and mitochondrial-supporting properties. This study aimed to investigate whether pre-conditioning with PQQ during pregnancy could mitigate adverse effects induced by lipopolysaccharide (LPS)-mediated inflammation in mice.

Methods

Pregnant mice were randomly assigned to three groups: control, LPS, and LPS + PQQ. On gestational day (GD) 16.5, mice in the LPS groups were intraperitoneally injected with either a single dose of 3 μg/mouse (moderate inflammation)

SUBMITTER: Han Y 

PROVIDER: S-EPMC12286791 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature