The predictive value of hsCRP/HDL-C ratio for cardiometabolic multimorbidity in middle-aged and elderly people: evidence from a large national cohort study.

ABSTRACT:

Background

Cardiovascular disease is associated with inflammation and dysregulated lipid metabolism. This study aimed to investigate the predictive value of high-sensitive C-reactive protein to high-density lipoprotein cholesterol ratio (CHR) in assessing the risk of developing cardiometabolic multi-morbidity (CMM) within the Chinese population.

Methods

A cohort of 8,187 participants were selected from the China Health and Retirement Longitudinal Study (CHARLS) and divided into four groups based on the quartile of CHR. To evaluate the association between CHR and CMM, we employed multivariable Cox proportional hazards regression, logistic regression, and restricted cubic splines (RCS) analysis. Subgroup analyses and interaction tests were conducted to further explore these re

SUBMITTER: Li S 

PROVIDER: S-EPMC12286803 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature