Effects of one-week intake of different edible oils on the urinary proteome of rats.

ABSTRACT:

Objective

To investigate the effects of different edible oils on the rat body, we analyzed alterations in the urinary proteome and post-translational modifications (PTMs) following a one-week intake of olive oil, butter, lard, hydrogenated vegetable oil, and rapeseed oil.

Methods

Thirty male Wistar rats (7 weeks old, ~200 g) were randomly allocated into six groups (n = 5 per group). Group A served as the control group, while groups B-F were administered different edible oils. The daily intakes were calculated, respectively, according to the "2015-2020 Dietary Guidelines for Americans" and the "Dietary Guidelines for Chinese Residents." Urine samples collected after 1 week were analyzed using label-free quantitative proteomics via LC-MS/MS. Differentially expressed pro

SUBMITTER: Su Y 

PROVIDER: S-EPMC12286817 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature