Patterns of inflammation and immune activation by coreceptor use in people living with HIV-1.

ABSTRACT:

Introduction

Human immunodeficiency virus type 1 (HIV-1) utilizes either the CCR5 (R5) or CXCR4 (X4) coreceptor for host cell entry. Coreceptor switching from R5 to X4 and elevated immune activation have been associated with disease progression. X4-tropic HIV-1 is predominantly observed in the late stage of infection, when the immune environment characterized by chronic activation is optimal for their replication. The aim of this study was to determine viral tropism in late HIV presenters and who have not previously received treatment in Mexico City and its relationship with markers of chronic immune activation.

Methods

A cross-sectional study was conducted on 122 people living with HIV (PLWH) recruited from two public health services. Viral tropism was determined using next

SUBMITTER: Guerra-Castillo FX 

PROVIDER: S-EPMC12286835 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature