Betaine alleviates obesity-related metabolic disorders in rats: insights from microbiomes, lipidomics, and transcriptomics.

ABSTRACT:

Background

Betaine is a natural food component that plays an important role in improving body composition, but the details of its effects on adipose tissue remains to be elucidated. Here, we hypothesize that betaine can alleviate obesity-related metabolic disorders, thus gut microbiota, transcriptomics and lipidomics were used to investigate the obesity-alleviating effects of betaine on high-fat diet (HFD)-fed rats.

Methods

In this study, rats fed a HFD were subjected to an 8-week oral intervention with betaine. We measured changes in body weight (BW), blood lipid profiles, and gastrointestinal hormones to assess therapeutic effects. The epididymal white adipose tissue was extracted and stained to evaluate the pathological morphology of adipocytes. The structure of the rat g

SUBMITTER: Wang X 

PROVIDER: S-EPMC12286965 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature