The role of teichoic acids of bifidobacteria in driving the interaction with the human host.

ABSTRACT: An in silico survey carried out in this study, performed on more than 3,000 publicly available bifidobacterial genome sequences, revealed clear differences in genes predicted to be involved in teichoic acid (TA) biosynthesis at inter-species level, indicating that only a small number of species possess a specific cluster for the production and assembly of these cell envelope-associated structures. Among these, Bifidobacterium bifidum represents a key member of the human gut microbiota at the early stages of life. Here, we show differences in the transcriptomic profiles of genes predicted to be involved in TA biosynthesis of three different strains of B. bifidum PRL2010 following exposure to human intestinal epithelial cells, suggesting a strain-specific and host-mediat

SUBMITTER: Longhi G 

PROVIDER: S-EPMC12286996 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature