Repetitive transcranial magnetic stimulation across neurodegenerative diseases: a systematic review and dose-response meta-analysis.

ABSTRACT:

Objective

We summarized the existing clinical evidence of repetitive transcranial magnetic stimulation (rTMS) for Parkinson's Disease (PD) and Alzheimer's Disease (AD) and conducted a series of dose-response meta-analyses to determine the curve relationship between the number of pulses and the effect size of the treatment.

Methods

Existing evidence was retrieved from five databases, and relevant outcome data on rTMS treatment for motor and non-motor symptoms of PD and AD were collected. Data were analyzed using R software to assess effect size using standardized mean differences (SMD) and 95% confidence intervals (CI). Heterogeneity testing was performed to assess differences in efficacy among the evidence, and restricted cubic spline (RCS) was used to fit the dose-response

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12287036 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature