A rapid-release pure iodine coating on titanium implants to mitigate acute periprosthetic infections.

ABSTRACT:

Background

Periprosthetic infections remain a significant challenge in orthopedic surgeries, primarily due to bacterial biofilm formation on implant surfaces. To address this issue, we developed a novel iodine-based coating on titanium implants designed to rapidly release iodine, thereby preventing acute infections. The efficacy and safety of this coating were assessed through both in vitro experiments and an in vivo rabbit model.

Methods

The iodine coating was applied to titanium implants using electrophoretic deposition. The coated implants were characterized using scanning electron microscopy (SEM), X-ray fluorescence spectroscopy (XRF), and energy-dispersive spectroscopy (EDS). In vitro studies included antibacterial assays, iodine release kinetics,

SUBMITTER: Zhang YQ 

PROVIDER: S-EPMC12287049 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature