Prediction of long-term major adverse cardiac events after myocardial infarction: value of combination of inflammatory biomarkers and GRACE score.

ABSTRACT:

Objective

This study aims to investigate the prognostic value of integrating inflammatory biomarkers with the established Global Registry of Acute Coronary Events (GRACE) risk score for predicting clinical outcomes in patients with myocardial infarction (MI).

Methods

This prospective, single-center study enrolled adult MI patients admitted to the coronary care unit at Zhongshan Hospital, Fudan University. Blood samples were collected to measure inflammatory markers (IL-1β, sIL-2R, IL-6, IL-8) and myocardial biomarkers. The Gensini score and GRACE score were calculated for each patient. The primary endpoint was the post-MI occurrence of a composite of major adverse cardiovascular events (MACE), including cardiovascular death, non-fatal MI, and non-fatal ischemic stroke. Predi

SUBMITTER: Tian D 

PROVIDER: S-EPMC12287059 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature