Salidroside inhibits melanin synthesis and melanoma growth via mTOR and PI3K/Akt pathways.

ABSTRACT:

Background

Melanomas are caused by the malignant transformation of melanocytes. Numerous studies have demonstrated that the tyrosol components of salidroside inhibit tyrosinase activity. The PI3K/Akt/mTOR signaling pathway plays a crucial role in biological pigment synthesis. However, how salidroside achieves its anti-melanoma effect in melanoma by regulating PI3K/Akt/mTOR remains poorly understood. This study aimed to explore the effect of salidroside on PI3K/Akt/mTOR in melanoma, which plays a role in regulating melanogenesis.

Methods

Network pharmacology was predicted that salidroside may exert an anti-melanoma effect through modulating melanin synthesis functions and signaling pathways. Zebrafish whole-embryo in situ hybridization, RT-qPCR, melanin synthesis and t

SUBMITTER: Ouyang Q 

PROVIDER: S-EPMC12287071 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature