Associations of lung function impairment and biological aging with mortality and cardiovascular disease incidence: findings from UK biobank participants.

ABSTRACT:

Background

Lung function impairment, including preserved ratio impaired spirometry (PRISm) and airflow limitation (AL), is associated with increased risks of mortality and cardiovascular disease; however, the underlying biological mechanisms remain poorly understood. This study aimed to investigate the mediating role of biological aging, as well as the interactions and joint effects of lung function impairment and biological aging on adverse health outcomes.

Methods

A total of 349,456 UK Biobank participants (aged 40-69 years) were categorized into normal, PRISm, and AL groups based on baseline spirometric measurements. Biological aging was assessed using phenotypic age acceleration (PhenoAgeAccel) and frailty phenotype. PhenoAgeAccel was calculated using algorithms based on

SUBMITTER: Chen J 

PROVIDER: S-EPMC12287072 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature