Systemic inflammatory response markers improve the discrimination for prognostic model in hepatocellular carcinoma.

ABSTRACT:

Background/purpose of the study

We aimed to evaluate the performance of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and their combination (combined NLR-PLR, CNP) in predicting overall survival (OS) and recurrence-free survival (RFS) in a large cohort of unselected hepatocellular carcinoma (HCC) patients.

Methods

Training and validation cohort data were retrieved from the Italian Liver Cancer (ITA.LI.CA) database. The optimal cut-offs of NLR and PLR were calculated according to the multivariable fractional polynomial and the minimum p value method. The continuous effect and best cut-off categories of NLR and PLR were analyzed using multivariable Cox regression analysis. A shrinkage procedure adjusted over-fitting hazard ratio (HR) estimates of be

SUBMITTER: Rocco A 

PROVIDER: S-EPMC12287231 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature