A highly annotated drug combination resource for catalyzing precision combinatorial therapy.

ABSTRACT: Combinations of cancer drugs have the potential to overcome resistance, improve the response rate of existing drugs and reduce dose-limiting toxicity associated with single agents. Existing drug combination databases only provide response data, such as synergy scores between two drugs, without important contextual information to assist oncologists in matching their patients with these combinations in an evidence-based way. To address this gap, we developed a cancer drug combination database (named as OncoDrug+) by manually collecting and integrating drug combinations and corresponding evidences from FDA databases, clinical guidelines, clinical trials, clinical case reports, patient-derived tumor xenograft models, cell line models and bioinformatics predictions. OncoDrug+ includes 7895 data

SUBMITTER: You T 

PROVIDER: S-EPMC12287253 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature