Gait instability is a more specific predictor of corticospinal tract function than gait speed in clinically stable multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) research requires new, more sensitive, behavioral biomarkers that map to subtle central nervous system injury. Although gait speed, as measured using the Timed 25 Foot Walk Test, is used clinically to track MS progression, it is less useful in people with MS who do not have overt gait impairment. This study aimed to identify specific spatiotemporal gait parameters that predict corticospinal tract (CST) function in individuals with MS. We recruited consecutive patients attending a neurology clinic and evaluated CST excitatory and inhibitory function using single pulse transcranial magnetic stimulation of the primary motor cortex representation of the first dorsal interosseous muscle. We generated excitatory and inhibitory recruitment curves by calculating the area un

SUBMITTER: Bilek F 

PROVIDER: S-EPMC12287266 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature