Transcription of GABA_A receptor subunits in circulating monocytes and association to emotional brain function in premenstrual dysphoric disorder.

ABSTRACT: Premenstrual dysphoric disorder (PMDD) has been hypothesized to be related to an altered sensitivity of the γ-aminobutyric acid type A (GABA_A) receptor to progesterone-derived neurosteroids. GABA_A receptor sensitivity to neurosteroid-modulation is dependent on its subunit composition. In the present study, we used quantitative reverse transcription polymerase chain reactions (RT-qPCR) to compare messenger ribonucleic acid (mRNA) expression of GABA_A receptor subunits in peripheral mononuclear cells (PBMCs) across the menstrual cycle in 29 women with PMDD and 27 controls. We related mRNA subunit expression to serum levels of neurosteroids and to functional activation of the amygdala, a key brain region involved in emotion generation, measured using functional

SUBMITTER: Stiernman L 

PROVIDER: S-EPMC12287299 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature