Association between vitamin D receptor gene variants and the risk of type 2 diabetes mellitus in a Ghanaian population.

ABSTRACT: Gene variants of the vitamin D receptor (VDR) have been linked to the alterations of the vitamin D metabolic pathway and thus a candidate risk gene for developing type 2 diabetes mellitus (T2DM). However, the association between VDR gene variants and vitamin D status as well as susceptibility to T2DM in the Ghanaian population have not been explored. This study assessed VDR gene variants, vitamin D status and susceptibility to T2DM. In a 1:1 matched case-control study, 100 clinically diagnosed T2DM patients visiting the Greenshield Hospital at Sefwi Bekwai and 100 apparently healthy non-diabetic controls living in same environs were recruited. Venous blood samples were obtained for biochemical analyses. Lipid profile was estimated spectrophotometrically and serum vitamin D was determined b

SUBMITTER: Arhin-Aidoo F 

PROVIDER: S-EPMC12287319 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature