Comparison between long-acting pegylated and daily recombinant human growth hormone for pediatric growth hormone deficiency a systematic review.

ABSTRACT: This systematic review aims to summarize the therapeutic benefits and safety profile of long-acting PEGylated recombinant human growth hormone (PEG‑rhGH) compared with daily recombinant human growth hormone (DGH) in pediatric growth hormone deficiency (PGHD) participants. We conducted an extensive literature review utilizing multiple databases, and evaluated change in height standard deviation score (∆Ht-SDS) as the primary outcome. Secondary outcomes included change in height velocity (∆HV) and incidence of total adverse events (AEs). The meta-analysis focused on comparing the standard dose of PEG‑rhGH (0.20 mg/kg/w) and DGH. The systematic review encompassed ten studies involving a total of 1,393 participants. In RCTs and cohort studies, ∆Ht-SDS at 6 months showed no significant differen

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12287356 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature