MT1JP/miR-103a-3p induce pyroptosis and regulate the tumor immune microenvironment in gastric cancer.

ABSTRACT: Immune checkpoint blockade (ICB) has made great progress in treating cancer, regulating the tumor immune microenvironment can improve the efficacy of ICB and has become a major focus. Pyroptosis, as a new form of cell death, has been reported in a few diseases to activate cellular immune responses due to the release of inflammatory factors. This may offer a new approach for regulating the tumor immune microenvironment. MT1JP plays an important role in gastric cancer, but its mechanism of pyroptosis and immunity is unclear. Bioinformatics analysis combined with qRT-PCR revealed the expression levels of MT1JP and miR-103a-3p in GC cells and tissues, and their interactions were revealed by dual-luciferase assay and rescue experiment. The effects of MT1JP on GC cell proliferation, invasion, an

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12287438 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature