Analysis and mining of L-ornithine L-aspartate adverse events based on FAERS database.

ABSTRACT: L-ornithine L-aspartate (LOLA) is indicated for reducing blood ammonia levels and alleviating symptoms of hepatobiliary disorders. Data mining of adverse events associated with LOLA was carried out in the FDA Adverse Event Reporting System database. The aim was to explore its potential medication risks and offer more reasonable and safe references for clinical medication. This study retrieved and extracted adverse event reports related to LOLA from the FAERS database from 2004Q1 to 2024Q3. The main method utilized was the reporting odds ratio for the detection of risk signals related to LOLA. In total, 413 adverse event reports where LOLA was the primary suspect drug were recognized, and a sum of 670 adverse events were reported. These reports mainly came from patients aged 40-65 and older

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12287519 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature