Macrophage-T cell interactions promote SLAMF1 expression for enhanced TB defense.

ABSTRACT: CD4+ T cells are crucial for protective immunity to intracellular pathogens. In addition to secreting cytokines, CD4+ T cells promote control of Mycobacterium tuberculosis infection through cognate interactions with macrophages, but the mechanism has been unclear. Here, we show that SLAMF1/CD150 is highly and uniquely induced in macrophages by antigen-specific interactions with CD4+ T cells. In macrophages, SLAMF1 enhances the generation of reactive oxygen species and restricts Mtb replication. Mtb-infection of mice promotes SLAMF1 expression specifically on infected macrophages, not uninfected bystanders. SLAMF1 expression depends on adaptive immunity and also autophagy. Moreover, Slamf1^-/- mice have higher Mtb burden and more rapid disease progression than wild type mice. Usin

SUBMITTER: Krishna Prasad GVR 

PROVIDER: S-EPMC12287521 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature