Exosomal tsRNA-Gly-5-0007 may be used as a diagnostic marker for colorectal cancer.

ABSTRACT: Colorectal cancer is one of the common malignant tumors nowadays, with the highest mortality rate among cancers, and most patients have metastasis when diagnosed. Exosomes contain bioactive molecules such as RNA, which can participate in signal transduction between cells. tRF is a new type of non-coding small RNA, which plays an important role in the progression of cancer. The purpose of this study is to explore the value of exosomal tRF as a biological diagnostic marker for colorectal cancer. Through the use of transmission electron microscopy (TEM), qNano, and western blot, exosomes obtained from the serum of both healthy people and patients with colorectal cancer were characterized; the expression of tRNA-Gly-5-0007 was validated by real-time quantitative PCR (qRT-PCR) in the exosome of

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12287527 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature