Uncovering the Associations of LILRB4 Genotypes With Parkinson's Disease: From Clinical Traits to Potential Pathologies.

ABSTRACT:

Background

Leukocyte immunoglobulin-like receptor B4 (LILRB4) has been shown to be associated with susceptibility to neurodegenerative diseases. This study was aimed at investigating the relationships between LILRB4 and the risk of developing PD, as well as its clinical characteristics and pathology.

Method

We analyzed 197 healthy controls and 606 PD patients from the Parkinson's Progression Marker Initiative (PPMI) study. The associations of LILRB4 loci with image data, CSF biomarkers, and clinical scales at baseline were assessed using multiple linear models.

Results

Dopamine transporter (DAT)-SPECT results showed that the striatal binding ratios (SBR) in the right caudate (β = 0.160, 95% CI = 0.076-0.244, P_c = 0.002), right putamen (β = 0.135, 95% CI = 0

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12287542 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature