Circadian rhythmicity in prepulse inhibition of the acoustic startle response: A study of chronotype and time-of-day effects in young healthy adults.

ABSTRACT:

Background

Prepulse inhibition (PPI) of the acoustically elicited startle response is a widely used cross-species measure of sensorimotor gating. It is known to be reduced in various psychiatric disorders. Given previous reports of (a) disrupted PPI in young adults following overnight sleep deprivation and (b) disrupted sleep-wake cycles and psychiatric disorders being more common in evening than morning chronotypes, it is possible that there are chronobiological influences on human PPI.

Aims

We investigated chronotype, time of day (ToD) and synchrony effects (i.e. optimal functioning at preferred ToD) in acoustic PPI in young healthy adults.

Methods

Thirty-six adults, selected from a larger pool (N = 213) to represent morning, intermediate or evening chronotyp

SUBMITTER: Chauhan S 

PROVIDER: S-EPMC12287558 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature