GABA and Glx levels in cortico-subcortical networks predict catecholaminergic effects on response inhibition.

ABSTRACT:

Background

Cortico-subcortical networks play a fundamental role in cognitive control. Within these circuits, neurotransmitters such as gamma-aminobutyric acid (GABA), glutamate, and catecholamines crucially modulate response control and (motor) response inhibition. Despite the evident interrelation between these transmitter systems, the role of baseline GABA and glutamate-glutamine (Glx) levels in predicting/influencing catecholaminergic effects has remained rather unclear.

Aims

Addressing this knowledge gap, we investigated the question how much (and which facets) of behavioral effects attributed to catecholamines are due to GABAergic and glutamatergic levels in control-relevant cortical networks.

Methods

Using proton-magnetic resonance spectroscopy, we assessed base

SUBMITTER: Koyun AH 

PROVIDER: S-EPMC12287562 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature