Centrally-acting opioid receptor antagonists as a treatment for antipsychotic-induced weight gain: A systematic review and meta-analysis of clinical trial data.

ABSTRACT:

Background

Antipsychotic-induced weight gain (AIWG) is a major concern in psychiatry, where there is a mortality gap between those with mental illness, particularly schizophrenia, and the general population. One development proposed is using centrally-acting opioid receptor antagonists (CORAs) such as naltrexone and samidorphan.

Objective

The systematic review and meta-analysis evaluated the available human clinical trial data on the effect of CORA on AIWG.

Methodology

Four online databases (MEDLINE, EMBASE, PsycINFO, and Cochrane) were searched for randomized-controlled trials (RCTs) on the topic. The primary outcome was change in bodyweight. Secondary anthropometric outcomes included percentage bodyweight change, BMI change, and absolute risk of weight gain. Meta-an

SUBMITTER: Lee K 

PROVIDER: S-EPMC12287564 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature