Characterizing Variability in Non-Invasive Hydration Monitoring Using Raman Spectroscopy.

ABSTRACT: Significant dehydration can increase thermoregulatory and cardiovascular strain and impair physical and cognitive performance. Despite these negative effects, there are currently no objective, non-invasive tools to monitor systemic hydration. Raman spectroscopy is an optical modality with the potential to fill this gap because it is sensitive to water, provides results quickly, and can be applied non-invasively. In this work, high wavenumber Raman spectroscopy has been developed toward detection of systemic hydration via validation with tissue-mimicking phantoms, followed by three in vivo feasibility studies to investigate the relationship between spectral features and systemic hydration. The area under the curve (AUC) of the water bands and the ratio of water bands to CH bands are Raman-d

SUBMITTER: Rourke-Funderburg AS 

PROVIDER: S-EPMC12287566 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature