Electron microscopic findings predict clinical outcomes in patients with non-ischaemic cardiomyopathy.

ABSTRACT:

Aims

Electron microscopy reveals microstructural alterations in cardiomyocyte nuclei and myofilaments in non-ischaemic cardiomyopathy (NICM), particularly in dilated cardiomyopathy (DCM). Nevertheless, the correlation between such observations and clinical outcomes, including prognosis and left ventricular reverse remodelling (LVRR), remains unclear. This study aimed to examine the association between electron microscopic findings and outcomes in patients with NICM.

Methods

In this multicentre, prospective, observational study, 170 patients with NICM with reduced ejection fraction (EF) < 40%, scheduled for diagnostic endomyocardial biopsy and optimization of medical therapies, were enrolled. Electron microscopic findings of cardiomyocytes such as discontinuous or continuous

SUBMITTER: Higuchi R 

PROVIDER: S-EPMC12287787 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature