Mono and combination therapies in pulmonary arterial hypertension patients with comorbidities: A COMPERA analysis.

ABSTRACT:

Aims

Pulmonary arterial hypertension (PAH) is often diagnosed in elderly patients with comorbidities. Although initial monotherapy is recommended for these patients, the value of combination therapy remains unclear. Here, we compare the efficacy of initial monotherapy and combination therapy in PAH patients with cardiovascular comorbidities.

Methods and results

Data from adult patients with incident pre-capillary PAH and cardiovascular comorbidities from the COMPERA database (European registry for PH) were analysed. A matched-pair analysis of patients treated with monotherapy versus combination therapy based on age, sex, WHO functional class (FC) and 4-strata risk at baseline was performed. The matching strategy identified 216 pairs of PAH patients with cardiovascular comorb

SUBMITTER: Skowasch D 

PROVIDER: S-EPMC12287794 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature