Identification of serum C4BPA as a potential diagnostic marker of right ventricular remodelling via proteomic analysis.

ABSTRACT:

Aims

Right ventricular (RV) remodelling, a progressive condition characterized by maladaptive cardiac structural and functional changes, primarily results from prolonged pressure overload in patients with pulmonary hypertension (PH). Accurate, universal and easy-to-use biomarkers for assessing the severity of RV remodelling are lacking. This study aimed to identify serum proteins as potential biomarkers of RV remodelling using high-throughput proteomic analysis-based screening.

Methods

Sprague-Dawley rats were subjected to sham surgery (control group) or pulmonary artery banding for 4 weeks with 2.3-mm diameter and 1.8-mm diameter rubber rings to induce mild and severe RV modelling, respectively. Serum proteomic profiling revealed 170 differentially expressed serum proteins

SUBMITTER: Wang X 

PROVIDER: S-EPMC12287822 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature